ELP

Composition:
Each ELP® film-coated tablet contains Escitalopram Oxalate equivalent to 10 mg of Escitalopram.

Pharmacology:
Escitalopram is a selective serotonin reuptake inhibitor (SSRI) with high affinity for the primary binding site. Escitalopram also binds to the allosteric site on the serotonin transporter with 1000-fold lower affinity. Allosteric modulation of the serotonin transporter enhances the binding of escitalopram to the primary binding site, resulting in more complete inhibition of serotonin reuptake. Escitalopram has no or low affinity for a number of receptors, including 5-HT1A, 5-HT2, DA D1 and D2 receptors, α1, α2, and β adrenoceptors, histamine H1 receptors, muscarinic cholinergic receptors, benzodiazepines, and opioids.
Serotonin reuptake inhibition is the sole mechanism of action explaining the pharmacological and clinical effects of escitalopram. Escitalopram is the S-enantiomer of the racemate (citalopram) and is the enantiomer associated with therapeutic activity. The R-enantiomer is not inert but counteracts the serotonin increase and consequent pharmacological properties of the S-enantiomer.

Indications:
– Treatment of major depressive episodes
– Treatment of panic disorder with or without agoraphobia
– Treatment of social anxiety disorder (social phobia)
– Treatment of generalized anxiety disorder
– Treatment of obsessive-compulsive disorder

Dosage and Administration:
Depression
Adults: Initial dose: 10 mg, taken once daily. The dose may be increased to a maximum of 20 mg upon doctor’s recommendation.
Elderly: Initial dose: 5 mg, taken once daily. The dose may be increased to a maximum of 10 mg per day depending on the patient’s condition.
Anxiety disorders
Adults: Initial dose: 10 mg, taken once daily. The dose may be increased to a maximum of 20 mg per day upon doctor’s recommendation.
Elderly: Initial dose: 5 mg, taken once daily. The dose may be increased to a maximum of 10 mg per day depending on the patient’s condition.
Panic disorder
Adults: Initial dose: 5 mg, taken once daily for one week. The dose may be increased to 10 mg per day the following week. In severe cases, the doctor may increase the dose again (to a maximum of 20 mg per day).
Elderly: Initial dose: 5 mg, taken once daily. The dose may be increased to a maximum of 10 mg per day depending on the patient’s condition.
Social anxiety disorder
Adults: Initial dose: 10 mg, taken once daily for one week. The dose can be reduced to 5 mg or increased to a maximum of 20 mg per day depending on your body’s response to the medication.
Elderly: Initial dose: 5 mg, taken once daily. The dose can be increased to a maximum of 10 mg per day depending on the patient’s condition.
Obsessive-compulsive disorder
Adults: Initial dose: 10 mg, taken once daily. The dose can be increased to a maximum of 20 mg as recommended by your doctor.
Elderly: Initial dose: 5 mg, taken once daily. The dose can be increased to a maximum of 10 mg per day depending on the patient’s condition.

Presentation and Registration Number:
ELP® Box, 3 strips @ 10 film-coated tablets Reg. No.: DKL 2408028217A1

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