Each VASTAN® 80 film-coated tablet contains Valsartan 80 mg
Each VASTAN® 160 film-coated tablet contains Valsartan 160 mg
Valsartan is an orally active, potent, and specific angiotensin II receptor antagonist. Valsartan acts selectively on the AT1 receptor subtype, which is responsible for the known action of angiotensin II. The magnitude of the increase in plasma AT2 following AT1 receptor blockade with Valsartan can stimulate unlocking of the AT2 receptor, which appears to offset the effects of the AT1 receptor. Valsartan does not inhibit ACE, also known as quinine II, which converts Angiotensin I to Angiotensin II and degrades bradykinin. Since no effect of ACE inhibitors was found and ineffectiveness of bradykinin or substance P, angiotensin II antagonists have no effect on cough. Valsartan does not bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation.
Valsartan is indicated for the treatment of hypertension. It can also be used alone or in combination with other antihypertensive drugs.
Valsartan is indicated for the treatment of heart failure (NYHA class I-IV) in patients who are intolerant of enzyme-converting angiotensin inhibitors. Valsartan significantly reduces the need for hospitalization for people with heart failure. Valsartan has benefits when used at doses adequate to ACE inhibitors.
Post Myocardial Infarction
Valsartan is indicated to improve survival after myocardial infarction in patients with stable signs, symptoms or radiological evidence of left ventricular failure and/or left ventricular systolic dysfunction.
80 mg once daily, and has no effect on differences in race, age, or sex. The antihypertensive effect usually lasts for 2 weeks and the maximum effect can be seen after 4 weeks. For patients whose blood pressure is not well controlled, the daily dose may be increased to 160 mg, or a diuretic may be added. Valsartan can also be given with other antihypertensives.
40 mg twice daily. Titrate doses up to 80 mg and 160 mg twice daily should be given in divided doses, as tolerated by the patient. Consider reducing the dose when co-administered with diuretic drugs. The maximum Dodid per day that can be given is 320 mg in divided doses. Concomitant use with ACE inhibitors and beta blockers is not recommended.
Evaluation of patients with heart failure should always be monitored for kidney function.
Post Myocardial Infarction
Therapy can be started 12 hours after myocardial infarction. After an initial dose of 20 mg twice daily, therapy with Valsartan should be titrated to 40 mg, 80 mg and 160 mg twice daily for several weeks. The recommended initial dose is 40 mg in divided doses. The target dose of 160 mg twice daily should be based on the patient’s tolerability of Valsartan during titration. If symptoms of hypotension and renal dysfunction occur, the dose should be reduced.
Presentation and Registration Number:
VASTAN® 80 Film-coated tablets Box, 3 strips @ 10 film-coated tablets No. Reg.: DKL1808025317A1
VASTAN® 160 Film Coated Tablets Box, 3 strips @ 10 film coated tablets No. Reg.: DKL1808025317B1
ON MEDICAL PRESCRIPTION ONLY
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