Composition :

Each tablet LOPITEN® 5 contains Amlodipine besylate equivalent with Amlodipine 5 mg

Each caplet LOPITEN® 10 contains Amlodipine besylate equivalent with Amlodipine 10 mg


Pharmacology :

Amlodipine has an antihypertensive action mechanism with a direct relaxation effect on vascular smooth muscle. The mechanism of action of Amlodipine against angina is not fully known but Amlodipine minimizes total ischemia by causing dilatation of peripheral arterioles thereby minimizing total peripheral resistance to cardiac work and Amlodipine also induces major coronary artery dilatation and coronary arterioles in both normal and ischemic conditions.

In hypertensive patients with once daily doses showed a significant decrease in blood pressure clinically both in the supine position and stand after the 24 hour interval. In angina patients with once daily doses, increase total exercise time and decrease the frequency of angina attacks. Amlodipine does not affect the effects of metabolites or lipid changes in plasma. Amlodipine is well absorbed and plasma peak levels are achieved within 6-12 hours after administration. Amlodipine distribution volume is approximately 20 L/kg. Half time elimination plasma is about 35-50 hours on taken once daily dosing. Steady levels in the blood is achieved 7-8 days with once daily dosing. Amlodipine is mostly excreted through urine.


Indication :

Amlodipine is used for the treatment of hypertension, chronic stable angina, vasospastic angina (angina prinzmetal or variant angina). Amlodipine can be given as a single therapy or combined with other antihypertensive and anti-anginal drugs.


Dosage :

Adults: the usual dose is 5 mg once daily. The dosage can be increased according to the patient’s condition up to a maximum dose of 10 mg. The recommended dose for stable chronic conditions or vasospastic angina is 5-10 mg. For patients with conditions liver failure and elderly patients starting with a lower dose.


Presentation and Registration Number:

LOPITEN®5 Tablet Box, 3 strips @ 10 tablets; DKL0808014210B1

LOPITEN®10 Caplet Box, 3 strips @ 10 caplets; DKL0708014204A1







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