Each LEGRA® 50 film coated tablet contains Sildenfil citrate equivalent to Sildenafil 50 mg
Each LEGRA® 100 film coated tablet contains Sildenafil citrate equivalent to Sildenafil 100 mg
Sildenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP) -specific phosphodiesterase type 5 (PDE 5). The physiological mechanism of penile erection involves the release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. Then NO activates the guanylate cyclase enzyme, which increases cGMP levels, causing relaxation of smooth muscle in the corpus cavernosum and improving blood flow. Sildenafil does not have a direct relaxant effect on the isolated human corpus cavernosa, but can increase the effect of NO by inhibiting PDE 5, which is responsible for cGMP degradation in the corpus cavernosum. When sexual stimulation causes NO local release, Sildenafil’s PDE 5 inhibition causes an increase in cGMP levels in the corpus cavernosum. Sildenafil at the recommended dosage does not have an effect if there is no sexual stimulation.
Sildenafil is indicated for the treatment of erectile dysfunction.
In most patients, the recommended dose is 50 mg, given as needed, approximately 1 hour before sexual activity. However, Sildenafil can be taken between 4 hours to 0.5 hours before sexual activity. Based on the effectiveness and tolerance, the dose can be increased until the recommended maximum dose is 100 mg or reduced to 25 mg. The frequency of using the recommended maximum dose is once a day.
Presentation and Registration Number :
LEGRA® 50 Film Coated Tablet; Box,1 strip @ 4 Film Coated Tablet; DKL1708024817A1
LEGRA® 100 Film Coated Tablet; Box,1 strip @ 4 Film Coated Tablet; DKL1708024817B1
ON MEDICAL PRESCRIPTION ONLY
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