Each EMP vial contains Esomeprazole sodium equivalent to Esomeprazole 40 mg
Esomeprazole proton pump inhibitor, is an S-isomer of omeprazole. Esomeprazole is a weak base that is concentrated and converted into an active form in a highly acidic environment in parietal cell secretory canaliculi. Esomeprazole specifically inhibits the enzyme H + / K + – ATPase, acid pump and secretion of basal acid and stimulated acid secretion. Esomeprazole blocks the final stages of acid production, resulting in inhibition of potent and long-term secretion of gastric acid.
Esomeprazole Injection is indicated for:
- Treatment of antisecretion of the stomach when oral administration is not possible as in:
– Gastro esophagal reflux (GERD) in patients with esophagitis and / or severe symptoms and reflux.
– Treat gastric ulcers caused by the treatment of nonsteroidal anti-inflammatory drugs
- Short-term maintenance of hemostasis and prevention of rebleeding in patients undergoing
endoscopy in acute gastric or intestinal ulcer bleeding.
Dosage and Administration:
- Treatment of antisecretion of the stomach when oral administration is not possible.
– Patients who cannot use the drug orally can be treated parenterally at a dose of 20-40 mg once a
day. Patients with reflux esophagitis are given a dose of 40 mg once a day. Patients who experience
reflux symptoms are treated with a dose of 20 mg once a day.
– Treatment of gastric ulcers caused by therapy for nonsteroidal anti-inflammatory drugs usually uses
a dose of 20 mg once a day.
Usually the duration of intravenous treatment is short-term treatment and transfer to oral
medication should be done as soon as possible.
- Short-term maintenance of hemostasis and prevention of re-exposure in patients undergoing
endoscopy in acute gastric or intestinal ulcer bleeding, a dose of 80 mg should be given by bolus
infusion for 30 minutes, followed by intravenous 8 mg / hour given for 3 days (72 hours)
The parenteral therapy period should be followed by gastric acid suppression with esomeprazole 40
mg tablets once daily for 4 weeks.
Pediatrics and adolescents
Intravenous Esomeprazole should not be used in Pediatrics and adolescents because there is no data available.
Treatment in patients with severe liver ulcer bleeding, given an initial dose of 80 mg of esomeprazole by bolus infusion followed by a dose of 4 mg / hour by intravenous infusion for 71.5 hours is expected to be sufficient.
Presentation and Registration Number:
EMP Powder Injection Box, 1 vial @ 40 mg ; DKL1708024644A1
ON MEDICAL PRESCRIPTION ONLY
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