Composition :

Each ml contains Dobutamine HCl equivalent to Dobutamine 50 mg


Pharmacology :

Dobutamine is a sympathomimetic amine with a strong stimulatory effect on 1 receptors and a weak effect on 2 and 1 receptors in the heart. Dobutamine directly stimulates 1 receptors in the heart to increase myocardial contractility and stroke volume, which results in an increase in cardiac output. Coronary blood flow and myocardial oxygen consumption are usually increased because of increased myocardial contractility. Unlike dopamine, dobutamine does not cause the release of endogenous norepinephrine.

Dobutamine reduces increased ventricular filling pressures (reduction of preload) and facilitates atrioventricular (AV) node conduction.



  • Absorption:

After intravenous administration, the onset of action of dobutamine occurs within 2 minutes. Peak plasma concentrations and drug effect occur within 10 minutes after the initial administration of the intravenous infusion.

  • Distribution :

It is not known whether dobutamine crosses the placenta or is distributed into breast milk.

  • Elimination:

The plasma half-life of dobutamine is approximately 2 minutes.

Dobutamine is metabolized in the liver and other tissues by catechol O-methyltransferase to an inactive compound, namely 3-O-methyldobutamine and conjugated with glucuronic acid. Dobutamine and 3-O-methyldobutamine conjugates are excreted mainly in the urine, and to a lesser extent excreted in the feces.



Assists in myocardial inotropy in the treatment of acute congestive heart failure or cardiogenic shock.


Dosage and Administration:

Administration of dobutamine by intravenous infusion, in a dose range of 2.5-4.0 g/kg/min. The usual dose is 2.5-10 g/kg/min. Dosage should be adjusted individually based on heart rate and heart rhythm, blood pressure and diuresis. Partial tolerance is possible if the infusion time exceeds 72 hours and in such cases an increase in the dose can be made.

Sterile solution for injection 250 mg/5 ml

The dosage is determined as follows:

1 ampoule

250 mg dobutamine in 1000 ml infusion solution

2 ampoule

500 mg dobutamine in 1000 ml infusion solution

4 ampoule

1000 mg dobutamine in 1000 ml infusion solution



Infusion rate


Infusion rate


Infusion rate


2,5 0,01 0,005 0,0025
5 0,02 0,01 0,005
7,5 0,03 0,015 0,0075
10 0,04 0,02 0,01
12,5 0,05 0,025 0,0125
15 0,06 0,03 0,015

The rate of infusion rate is associated with each dose, multiplied by the patient’s body weight. Therefore the rate of infusion is milliliters per minute.


For infusion: sterile solution for injection dissolved in 0.9% NaCl solution, 10% glucose solution or Ringer’s lactate. If stored at room temperature, the prepared infusion solution is stable for 24 hours and if stored in the refrigerator, stable for 30 hours.

Dobutamine should not be dissolved in alkaline solutions.


Storage and Expiration Limit:

Store at temperatures below 30oC. Protected by light. Do not store in the refrigerator or freezer.


Packaging :

DOMINE® Injection 250 mg/5 ml            Box, 5 ampoules @ 5 ml                  Reg Number. : DKL1908026343A1

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